ABSTRACT
A female adult dog, with a four-month history of pain and intense pruritus, which eventually resulted in sudden death, was referred for necropsy. Postmortem examination showed thoracic and abdominal serum-sanguineous exudates, multifocal infiltrative renal masses, and similar tumors in the heart. Histopathology revealed midsize infiltrative neoplastic proliferation composed of round cells, sparse cytoplasm, and large hyperchromatic nuclei. Immunohistochemistry revealed CD3+ and CD20-immunoexpression. Histopathological and immunohistochemical findings confirmed the diagnosis of epitheliotropic lymphoma with cardiac and renal metastasis.(AU)
Foi encaminhado para necropsia um cão adulto do sexo feminino, com histórico de dor e prurido intenso com evolução de quatro meses, que acabou resultando em morte súbita. O exame post mortem mostrou presença discreta de exsudato serossanguinolento em cavidades torácica e abdominal, massas renais infiltrativas multifocais e tumores semelhantes no coração. O exame histopatológico revelou proliferação neoplásica infiltrativa composta de células redondas, com citoplasma escasso, e grandes núcleos hipercromáticos. A análise imuno-histoquímica mostrou imunoexpressão CD3+e CD20. Os achados histopatológicos e imuno-histoquímico confirmaram o diagnóstico de linfoma epiteliotrópico com metástase cardíaca e renal.(AU)
Subject(s)
Animals , Female , Dogs , Heart Neoplasms/veterinary , Kidney Neoplasms/veterinary , Mycosis Fungoides/veterinary , Neoplasm Metastasis/diagnosis , Sezary Syndrome/veterinary , Autopsy/veterinary , Immunohistochemistry/veterinary , Lymphoma, T-Cell, Cutaneous/veterinaryABSTRACT
The present report describes a case of Sezary syndrome in a canine with lymphadenomegaly, generalized erithroderma, intense pruritus and disseminated cutaneous nodules and plaques. Biopsy samples were taken from cutaneous nodules and plaques and were diagnosed epitheliotropic T cell cutaneous lymphoma by histology and immunohistochemical stain. Bone marrow cytology confirms leukemia. Diagnosis of Sezary syndrome was achieved through clinical, hematological, citopathological, histopathological and immunohistochemical findings. The patient was treated with Madison-Wisconsin chemotherapy protocol, but died after two mouths of treatment